AJAP2301 - CME/CMLE - Leukocyte Chemotactic Factor 2 Amyloidosis (ALECT2) Distribution in a Mexican Population: An Autopsy Study-Leukocyte Chemotactic Factor 2 Amyloidosis (ALECT2) Distribution in a Mexican Population: An Autopsy Study

Leukocyte Chemotactic Factor 2 Amyloidosis (ALECT2) Distribution in a Mexican Population: An Autopsy Study

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The study on Leukocyte Chemotactic Factor 2 Amyloidosis (ALECT2) was conducted through autopsy analysis to assess its prevalence, organ involvement, and clinical associations in a Mexican population. The research found a 3.5% prevalence of amyloidosis in autopsies, with 1.8% being ALECT2 cases. ALECT2 deposits were commonly found in the kidneys, liver, spleen, and adrenal glands. Despite organ involvement, most cases remained asymptomatic, and no deaths were attributed to ALECT2. The study revealed a high prevalence of ALECT2 in the Mexican population, with kidney and liver being most commonly affected organs, along with frequent involvement of the spleen and adrenal glands. The study highlighted the need for further research into the subclinical effects of amyloid deposition in the spleen and adrenal glands. The analysis also discussed the genetic and functional aspects of LECT2 protein and emphasized the ethnic bias and prevalence of ALECT2, notably in Hispanic populations. Additionally, limitations of the study, such as the small sample size and retrospective clinical evaluation, were acknowledged. This research contributes to the understanding of ALECT2 amyloidosis, its organ distribution, and the clinical significance of organ involvement.

Keywords

Leukocyte Chemotactic Factor 2 Amyloidosis

ALECT2

Mexican population

autopsy analysis

organ involvement

prevalence

kidneys

liver

spleen

adrenal glands