AJHE2107 - CME/CMLE - Markers of Follicular Helper T Cells Are Occasionally Expressed in T-Cell or Histiocyte-Rich Large B-Cell Lymphoma, Classic Hodgkin Lymphoma, and Atypical Paracortical Hyperplasia: A Diagnostic Pitfall For T-Cell Lymphomas of...-Markers of Follicular Helper T Cells Are Occasionally Expressed in T-Cell or Histiocyte-Rich Large B-Cell Lymphoma, Classic Hodgkin Lymphoma, and Atypical Paracortical Hyperplasia: A Diagnostic Pitfall For T-Cell Lymphomas of T Follicular Helper Origin

Markers of Follicular Helper T Cells Are Occasionally Expressed in T-Cell or Histiocyte-Rich Large B-Cell Lymphoma, Classic Hodgkin Lymphoma, and Atypical Paracortical Hyperplasia: A Diagnostic Pitfall For T-Cell Lymphomas of T Follicular Helper Origin

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The study focuses on the expression of markers of follicular helper T cells (TFH) in various lymphoid proliferations, including angioimmunoblastic T-cell lymphoma (AITL), showing differential expression patterns in benign and malignant conditions. The study analyzed the expression of programmed death-1 (PD-1), C-X-C motif chemokine ligand 13 (CXCL13), B-cell lymphoma 6 protein (BCL-6), inducible costimulator (ICOS), and CD10 in different lymphomas and hyperplasias.<br /><br />The findings suggest that these TFH markers can be expressed in atypical paracortical hyperplasia, T-cell or histiocyte-rich large B-cell lymphoma, and classic Hodgkin lymphoma, potentially leading to diagnostic challenges in distinguishing T-cell lymphomas of TFH origin. Specifically, AITL tends to coexpress more than 2 TFH markers, while PTCL-NOS and PTCL-TFH show differential marker expression. Coexpression of multiple TFH markers was more common in AITL compared to PTCL-TFH.<br /><br />The study highlights the importance of interpreting TFH markers in conjunction with other clinical and pathological information. Caution is emphasized in diagnosing TCL-TFH based solely on TFH marker expression, especially when dealing with limited tissue samples. Understanding the varying expression profiles of TFH markers in different lymphoid proliferations is crucial for accurate diagnosis and patient management.

Keywords

TFH markers

AITL

PD-1

CXCL13

BCL-6

ICOS

CD10

diagnostic challenges

coexpression

tissue samples