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AJHE2110 - CME/CMLE - Practical Considerations and ...
Practical Considerations and Testing Nuances for t ...
Practical Considerations and Testing Nuances for the Detection of Lupus Anticoagulant
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Pdf Summary
The document discusses practical considerations and testing nuances for the detection of Lupus Anticoagulant (LA) with a focus on the importance of low Phospholipid (PL) screen results and test ratios. It reviews a study comparing patients with positive TR in paired LA testing despite negative low PL screens. The study found that borderline samples may still exhibit PL dependence and LA persistence, raising questions about the need for PL neutralization. The research also explored differences in patients with low, moderate, and high TRs, highlighting a link between higher TRs and prolonged activated partial thromboplastin time in some cases.<br /><br />Additionally, the study compared patients with positive dRVVT and SCT tests, noting varying clinical associations. Borderline dRVVT results were more common in pregnancy-related cases, while SCT true positivity was associated with autoimmune diseases. The document emphasizes the need for further studies to determine the significance of borderline LA results, especially in cases with negative screening results but positive TRs, and the importance of understanding differences in test performance based on test type and clinical subgroups. Ultimately, the document underscores the necessity for standardization in LA testing protocols to ensure accurate diagnosis and proper patient management.
Keywords
Lupus Anticoagulant detection
Phospholipid screen importance
Test ratios in Lupus Anticoagulant testing
PL dependence in borderline samples
LA persistence in borderline samples
PL neutralization in Lupus Anticoagulant testing
Activated partial thromboplastin time
dRVVT and SCT test comparison
Clinical associations of dRVVT and SCT tests
Standardization in LA testing protocols
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