AJHE2210 - CME/CMLE - How I Diagnose Mature T-Cell Proliferations by Flow Cytometry-How I Diagnose Mature T-Cell Proliferations by Flow Cytometry

How I Diagnose Mature T-Cell Proliferations by Flow Cytometry

Pdf Summary

The document is a review of diagnosing mature T-cell neoplasms, focusing on the importance of flow cytometry for assessing T-cell abnormalities. It covers the significance of identifying immunophenotypic aberrancies for accurate diagnosis, normal T-cell subsets, diagnostic pitfalls, and distinguishing between clonality and aberrancy in T-cell malignancies. The article emphasizes the complexities of T-cell neoplasms, the role of flow cytometry in detecting abnormalities, and challenges in interpreting results. It provides insights into abnormal findings using flow cytometry, including unique characteristics indicative of neoplasia. The text also discusses the impact of artifacts on interpretation and the importance of clonality assessment for diagnosing T-cell neoplasms. The document serves as a guide for clinicians and pathologists to understand and interpret T-cell abnormalities effectively using flow cytometry, with practical cases demonstrating the nuances in diagnosis and the necessity of specific markers and techniques for accuracy.

Keywords

mature T-cell neoplasms

flow cytometry

immunophenotypic aberrancies

T-cell subsets

diagnostic pitfalls

clonality

T-cell malignancies

abnormal findings

interpretation challenges

clonality assessment