AJHE2212 - CME/CMLE - Implementing Reticulocyte Hemoglobin into Current Hematology Algorithms: A Systematic Literature Review-Implementing Reticulocyte Hemoglobin into Current Hematology Algorithms: A Systematic Literature Review

Implementing Reticulocyte Hemoglobin into Current Hematology Algorithms: A Systematic Literature Review

Pdf Summary

The review article discusses the potential of reticulocyte hemoglobin (retic-Hb) as a stable and reliable marker for detecting iron deficiency and iron-deficiency anemia. Retic-Hb values were found to present a smaller range than ferritin, making interpretation less complex. The systematic literature review included studies from 2015 to 2022 that analyzed hemoglobin, MCV, and retic-Hb values. The results indicated that retic-Hb can detect iron deficiency earlier than current testing methods. The meta-analysis showed significant differences in retic-Hb values between controls, iron deficiency, and iron-deficiency anemia groups. Retic-Hb values less than 26 pg could distinguish iron-deficiency anemia, while values between 26 to 31.5 pg could indicate iron deficiency, with high sensitivity and specificity levels. The review suggests that retic-Hb could be a quick screening test for identifying these conditions, potentially improving diagnostic accuracy and reducing unnecessary testing.<br /><br />Iron deficiency is a common issue globally, leading to iron-deficiency anemia if left untreated. The document outlines the three stages of iron deficiency progression and emphasizes the slow onset of symptoms. It further explains how traditional methods of diagnosing anemia using CBC and iron panel tests may not detect iron deficiency until the final stage when body iron stores are significantly depleted. The introduction of retic-Hb as a screening test offers a faster alternative for early detection and monitoring of iron deficiency and anemia. Future studies are recommended to further explore this marker's validity across different age groups and underlying conditions to improve diagnostic accuracy and patient outcomes.

Keywords

reticulocyte hemoglobin

iron deficiency

iron-deficiency anemia

ferritin

MCV

hemoglobin

diagnostic accuracy

screening test

iron panel tests

patient outcomes