AJHE2301 - CME/CMLE - How I diagnose EBV-positive B- and T-cell Lymphoproliferative Disorders-How I diagnose EBV-positive B- and T-cell Lymphoproliferative Disorders

How I diagnose EBV-positive B- and T-cell Lymphoproliferative Disorders

Pdf Summary

The document explores the diagnosis of Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs), discussing B- and T-cell derivations, with a focus on challenges in differentiating benign and malignant lymphoproliferations. Clinical data, histological, immunophenotypic features, and EBV latency patterns are crucial for accurate diagnosis. The significance of EBV DNA copy numbers in blood for assessing immunosuppression is highlighted, along with two cases: systemic EBV T-cell lymphoma in children and EBV mucocutaneous ulcer in the elderly. The document underscores the importance of incorporating clinical and molecular aspects for precise diagnosis, mentioning clonality analysis and cytogenetic abnormalities as providing insights into pathogenesis. Differentiating between neoplastic and background EBV-infected cells is crucial. It concludes by stressing a comprehensive approach to accurately differentiate EBV-related lymphoproliferations based on clinical characteristics, morphology, immunophenotype, and molecular features. The complexity of diagnosing these disorders is further emphasized due to overlapping features with benign and malignant lymphoproliferations.

Keywords

Epstein-Barr virus

lymphoproliferative disorders

diagnosis

immunosuppression

clinical data

molecular features

pathogenesis

clonality analysis

cytogenetic abnormalities

neoplastic cells