AJHE2308 - CME/CMLE - Transformations of Marginal Zone Lymphomas and Lymphoplasmacytic Lymphomas: report from the 2021 SH/EAH Workshop-Transformations of marginal zone lymphomas and lymphoplasmacytic lymphomas Report from the 2021 SH/EAHP Workshop

Transformations of marginal zone lymphomas and lymphoplasmacytic lymphomas Report from the 2021 SH/EAHP Workshop

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The document discusses transformations of marginal zone lymphomas (MZL) and lymphoplasmacytic lymphomas, focusing on cases presented at a workshop. It highlights how these types of lymphomas may transform into diffuse large B-cell lymphoma (DLBCL) or other high-grade lymphomas, occasionally with EBV involvement. The most common transformation observed is to DLBCL, not otherwise specified, but transformations to classic Hodgkin lymphoma, high-grade B-cell lymphomas, and plasmablastic lymphomas are also noted. Molecular analysis revealed mutations such as MYD88 L265P in LPL cases, and clonally related transformations were identified in some instances. The importance of broad-based sequencing studies to aid in the diagnosis and classification of these transformations is emphasized. The document underscores the complex and diverse nature of transformations in MZL and LPL, the need for further studies to understand these processes better, and the role of molecular diagnostics in characterizing these lymphomas. It also addresses potential treatment implications based on molecular findings. The review provides a comprehensive overview of histologic transformations in these types of lymphomas, emphasizing the importance of molecular analysis in understanding and managing these transformations effectively.

Keywords

Marginal zone lymphoma

Lymphoplasmacytic lymphoma

Diffuse large B-cell lymphoma

EBV involvement

MYD88 L265P mutation

Clonally related transformations

Broad-based sequencing studies

Histologic transformations

Molecular diagnostics

Treatment implications