AJHE2309 - CME/CMLE - Progression of follicular lymphoma and related entities Report from the 2021 SH/EAHP Workshop-Progression of follicular lymphoma and related entities Report from the 2021 SH/EAHP Workshop

Progression of follicular lymphoma and related entities Report from the 2021 SH/EAHP Workshop

Pdf Summary

The workshop focused on transformations in lymphoid neoplasms, mainly B-cell lymphomas like follicular lymphoma (FL) progressing to aggressive forms due to additional genetic alterations. Detailed cases illustrated various transformations with changes in morphology, immunophenotype, and genetics, emphasizing the relevance of understanding molecular mechanisms for improved prognosis and therapeutic targets. Notable cases included transformations to TdT-positive aggressive lymphomas with poor outcomes and different subtypes like DLBCL, EBV-positive DLBCL, and mantle cell lymphoma progressing to a blastoid variant.<br /><br />The document underscores the importance of genetic alterations in determining prognosis, particularly MYC rearrangements in high-grade B-cell lymphomas. It also discusses challenges in diagnosing aggressive lymphomas with TdT expression and distinguishing between different subtypes for proper treatments. Additionally, it touches on cases resembling gray zone lymphomas and genetic changes impacting Mantle Cell Lymphomas.<br /><br />Overall, the study provides insights into genetic and molecular features of B-cell lymphomas, aiding in their classification and treatment decisions based on risk stratification.

Keywords

lymphoid neoplasms

B-cell lymphomas

follicular lymphoma

genetic alterations

molecular mechanisms

prognosis

therapeutic targets

aggressive lymphomas

MYC rearrangements

risk stratification