AJHE2310 - CME/CMLE - Transdifferentiation, phenotypic infidelity, progression and transformation in T/NK-cell neoplasms: report from the 2021 Workshop of the Society for Hematopathology and European Association for Haematopathology-Transdifferentiation, phenotypic infidelity, progression, and transformation in T/NK-cell neoplasms Report from the 2021 SH/EAHP Workshop

Transdifferentiation, phenotypic infidelity, progression, and transformation in T/NK-cell neoplasms Report from the 2021 SH/EAHP Workshop

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The review article explores transdifferentiation, progression, and phenotypic changes in T-cell and natural killer cell neoplasms, focusing on cases presented during a workshop. These cases reveal transdifferentiation between different cell lineages, phenotypic infidelity with aberrant expression of B-cell markers, and the importance of clonality studies in establishing relationships between primary and secondary neoplasms. Molecular characteristics like mutations in specific pathways were common in certain neoplasms. Furthermore, the document discusses cases of transformation and progression in mature T-cell neoplasms, emphasizing genomic alterations and clonal relationships across different neoplasms. Specific examples of transformation events and complexities involving coexistence with myeloid or B-cell neoplasms are highlighted, including insights into potential molecular mechanisms. The discussion on clonal architecture and oncogenic mechanisms provides a comprehensive understanding of the pathogenesis and clinical implications in T-cell neoplasms. Overall, the document underscores the significance of comprehensive phenotyping and molecular studies in diagnosing and managing these intricate cases of T/NK-cell neoplasms.

Keywords

transdifferentiation

progression

phenotypic changes

T-cell neoplasms

natural killer cell neoplasms

clonality studies

molecular characteristics

genomic alterations

clonal relationships

oncogenic mechanisms