AJHE2401 - CME/CMLE - Determination of Age-Dependent Bone marrow Normocellularity-Determination of Age-Dependent Bone marrow Normocellularity

Determination of Age-Dependent Bone marrow Normocellularity

Pdf Summary

The study aimed to determine the age-dependent normocellularity of bone marrow in a large patient cohort, focusing particularly on older adults. The research found that bone marrow cellularity decreases by approximately 3% per decade in adults, contrary to the previously assumed 10% per decade. The normocellularity range for individuals aged 18 to 90 years was established to be between 30% to 75%. The findings suggest a relatively stable cellularity among older individuals, indicating a slow decline in cellularity with age. The study analyzed 570 benign staging and donor bone marrows, revealing that normocellularity should be defined based on age groups rather than a linear model. The study highlighted a more gradual decline in cellularity with age, particularly stabilizing in individuals over the age of 70, with no significant decrease compared to those aged 60 to 69. This understanding of normal bone marrow cellularity is crucial for accurate disease management and assessment. The study proposed updated normocellularity definitions based on different age groups to reflect the observed changes in cellularity more accurately.

Keywords

bone marrow

normocellularity

age-dependent

older adults

cellularity decline

benign staging

donor bone marrows

age groups

disease management

normocellularity definitions