AJMB2202 - CME/CMLE - Leprosy Due to Mycobacterium lepromatosis: Literature Review and Report of A Family Cluster in Acapulco, Mexico-Leprosy Due to Mycobacterium lepromatosis: Literature Review and Report of A Family Cluster in Acapulco, Mexico

Leprosy Due to Mycobacterium lepromatosis: Literature Review and Report of A Family Cluster in Acapulco, Mexico

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The document discusses leprosy caused by Mycobacterium lepromatosis, a recently recognized cause of leprosy endemic in Mexico. The study reviews related literature and reports on a Mexican family cluster affected by this infection, highlighting the need for better surveillance and control measures. Mycobacterium lepromatosis was identified in a grandfather, mother, and two grandsons in the family. The index, the oldest grandson, likely contracted the infection from his maternal grandfather about 13 years ago. The study points out the clinical features of leprosy, including diffuse lepromatous leprosy (DLL) found in Mexico, with the disease showing severe manifestations. Genome-based PCR assays were developed to detect the specific bacillus in infected tissue, and the results confirmed the presence of M lepromatosis in the family members. The document also discusses the possible transmission routes within the family and the significance of genome data in understanding the pathogenicity and diversity of these leprosy agents. Furthermore, it touches upon the geographical distribution of M lepromatosis infections globally, emphasizing its prevalence in Mexico and other countries. The study concludes that M lepromatosis is a significant cause of leprosy, particularly in Mexico, and calls for continued efforts in surveillance and control to reduce the incidence of this infection.

Keywords

Mycobacterium lepromatosis

leprosy

Mexico

family cluster

surveillance

control measures

clinical features

diffuse lepromatous leprosy

genome-based PCR assays

transmission routes