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AJMP2202 - CME/CMLE - Investigation of SARS-CoV-2 ...
Investigation of SARS-CoV-2 Epsilon Variant and Ho ...
Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in A Single Large Health System during the 2020-2021 Winter Surge in Southern California
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Pdf Summary
The study focused on the investigation of the SARS-CoV-2 Epsilon variant (B.1.429/427) during the 2020-2021 winter surge in Southern California to determine if it led to increased hospitalizations and ICU admissions. Genomic surveillance on 231 unique patients showed that the frequencies of the Epsilon variant among outpatients, hospitalized patients, and ICU patients were similar, indicating no significant association with increased hospitalizations or ICU admissions. The study's findings suggest that the Epsilon variant is not linked to more severe outcomes. While other studies have shown conflicting results regarding the variant's virulence, this research adds valuable data to understanding the behavior of this past dominant variant. The study also highlighted the limitations, such as a relatively small sample size and potential biases in case selection and sequencing criteria. The decrease in prevalence of the Epsilon variant since June 2021 and the dominance of the Delta variant have shifted the focus of concern. The study contributes to the ongoing efforts to monitor and understand the dynamics of SARS-CoV-2 variants in the context of the evolving COVID-19 pandemic.
Keywords
SARS-CoV-2 Epsilon variant
B.1.429
B.1.427
Southern California
hospitalizations
ICU admissions
genomic surveillance
variant virulence
Delta variant
COVID-19 pandemic
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