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AJSP2103 - CME/CMLE - Characterization of the Peri ...
Characterization of the Peritumoral Atrophic Band ...
Characterization of the Peritumoral Atrophic Band and Nonneoplastic Renal Parenchyma in Radical Nephrectomy Specimens
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The study focused on characterizing the peritumoral atrophic band (PAB) in radical nephrectomy specimens to assess nonneoplastic renal parenchyma, particularly in diabetic nephropathy. The PAB exhibited increased scarring compared to distant parenchyma, with reliable detection of diabetic nephropathy within it. The PAB thickness did not correlate with tumor size. Mesangial sclerosis was prevalent in cases with diabetes and was reliably identified in the PAB. Identifying diabetic nephropathy is crucial for managing chronic kidney disease. The study highlights the importance of evaluating nonneoplastic renal tissue in nephrectomy specimens and the significance of the PAB in assessing renal pathologies when distant parenchyma is lacking. Recommendations include using distant parenchyma for assessing chronic renal injury, emphasizing the need for proper pathological examination to identify diabetic nephropathy, and involving renal pathologists for accurate evaluation. The study provides insights into utilizing the PAB for assessing renal diseases in nephron-sparing surgeries and emphasizes the importance of recognizing diabetic nephropathy early on to prevent disease progression and guide clinical interventions.
Keywords
peritumoral atrophic band
PAB
radical nephrectomy
nonneoplastic renal parenchyma
diabetic nephropathy
mesangial sclerosis
chronic kidney disease
renal pathologies
nephron-sparing surgeries
diabetic nephropathy management
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