AJSP2104 - CME/CMLE - Smoking Is Associated With Basal Cell Hyperplasia on Prostate Biopsy Specimens-Smoking Is Associated With Basal Cell Hyperplasia on Prostate Biopsy Specimens

Smoking Is Associated With Basal Cell Hyperplasia on Prostate Biopsy Specimens

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A study investigated the association between cigarette smoking and basal cell hyperplasia (BCH) in prostate biopsy specimens among men aged 50 to 75. The research analyzed data from the REDUCE trial, including 8,196 men with prior negative biopsies. Current smokers had a higher prevalence of BCH compared to former and never smokers, even after adjusting for various factors. While smoking is known to impact various health conditions, its association with BCH was previously unexplored. BCH, characterized by increased basal cell proliferation, was found in 1.3% of baseline biopsies. Smoking, an established risk factor for multiple diseases, including prostate cancer and benign prostatic hyperplasia, was independently linked to BCH in this study. Despite limited statistical power due to the low BCH prevalence, the findings suggest a potential connection between smoking and histologic changes in the prostate epithelium. The mechanisms underlying this association remain unclear. The study contributes to understanding the potential impact of smoking on prostate health, highlighting the need for further research on the causes and consequences of BCH. The research underscores the significance of exploring how smoking may affect prostate tissue beyond known risks like cancer and inflammation.

Keywords

cigarette smoking

basal cell hyperplasia

prostate biopsy specimens

REDUCE trial

men aged 50 to 75

current smokers

former smokers

never smokers

prostate health

histologic changes