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AJSP2105 - CME/CMLE - Thick Fibrous Septa on Liver ...
Thick Fibrous Septa on Liver Biopsy Specimens Pred ...
Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis
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Pdf Summary
The study focuses on the correlation between fibrous septa thickness on liver biopsy specimens and the development of decompensation in patients with compensated cirrhosis. Researchers examined 168 patients with compensated cirrhosis and observed that thick fibrous septa are associated with a higher risk of decompensation. Over a median follow-up of 50 months, 26% of patients developed clinical decompensation, with ascites being the most common complication. Univariate analysis showed that septal width, but not nodule size, was significantly associated with decompensation. Multivariate analysis confirmed that serum albumin levels and septal width were independent predictors of decompensation. The study suggests that thicker fibrous septa denote a worse prognosis in patients with compensated cirrhosis. Different histologic features can subclassify cirrhosis based on severity, with implications for prognosis and therapeutic decisions. The findings support the use of a semiquantitative histologic system for assessing fibrosis in cirrhosis and highlight the importance of recognizing fibrous septa thickness as a predictor of decompensation. The study provides insights into understanding the different stages of cirrhosis and their clinical implications, especially in stratifying patients with compensated cirrhosis for clinical research and treatment decisions.
Keywords
fibrous septa thickness
liver biopsy specimens
decompensation
compensated cirrhosis
semiquantitative grading
nodules size
viral causes
histologic features
prognostic information
ascites
nonselective beta-blocker therapy
septal width
nodules
serum albumin levels
prognosis
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