AJSP2202 - CME/CMLE - Sessile Serrated Adenoma with Dysplasia of the Colon - A Retrospective Pathology Review Focusing on Subtypes-Sessile Serrated Adenoma with Dysplasia of the Colon - A Retrospective Pathology Review Focusing on Subtypes

Sessile Serrated Adenoma with Dysplasia of the Colon - A Retrospective Pathology Review Focusing on Subtypes

Pdf Summary

The document explores a study focusing on sessile serrated adenomas with dysplasia (SSADs) of the colon, categorizing them into subtypes based on dysplasia characteristics and MLH1 immunostaining. The findings revealed the prevalence and significance of different subtypes, highlighting the heterogeneity in dysplastic components and the implications of MLH1 loss in predicting sessile serrated lesions in the colon background. The research observed a higher occurrence of females among SSAD cases, especially those with MLH1 loss, and noted a trend of dysplasia in SSAs occurring in older individuals with variations based on dysplasia grade. Although there was a stepwise progression in dysplasia grade over time, the document suggests that morphologically subclassifying SSADs may not be necessary for daily practice. Furthermore, it emphasizes the importance of complete endoscopic removal of SSADs due to their association with a rapid transition to carcinoma. The study recommends focusing on the characteristics of resulting cancer rather than the precursor polyp when making therapeutic decisions. It concludes by suggesting that further research is needed to determine the clinical relevance of SSAD subgroups and their impact on follow-up recommendations.

Keywords

sessile serrated adenomas with dysplasia

SSADs

colon

dysplasia characteristics

MLH1 immunostaining

subtypes

heterogeneity

MLH1 loss

prevalence

cancer transition