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Catalog
AJSP2207 - CME/CMLE - Pulmonary Pathology of End-S ...
Pulmonary Pathology of End-Stage COVID-19 Disease ...
Pulmonary Pathology of End-Stage COVID-19 Disease in Explanted Lungs and Outcomes After Lung Transplantation
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Pdf Summary
The document discusses pulmonary pathology in patients with chronic respiratory failure post-COVID-19, leading to lung transplantation. Findings include diffuse alveolar damage with fibrosis and neoangiogenesis, emphasizing the need for novel management strategies for end-stage COVID-19 lung disease. Detailed cases of lung transplant recipients highlight fibrosis, bronchiectasis, and post-acute sequelae of SARS-CoV-2 infection, with improvements post-transplant. Radiological and histological examinations reveal ongoing fibrosis, inflammation, and vascular changes, underscoring challenges in managing post-COVID-19 lung disease. The study suggests potential management strategies based on pathologic findings and references therapies like antifibrotic agents. Understanding pulmonary pathology in COVID-19 patients is crucial for developing effective treatments and managing chronic lung sequelae.
Keywords
pulmonary pathology
chronic respiratory failure
lung transplantation
fibrosis
neoangiogenesis
end-stage COVID-19 lung disease
lung transplant recipients
SARS-CoV-2 infection
antifibrotic agents
chronic lung sequelae
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