AJSP2209 - CME/CMLE - Solitary Fibrous Tumor With Extensive Epithelial Inclusions-Solitary Fibrous Tumor With Extensive Epithelial Inclusions

Solitary Fibrous Tumor With Extensive Epithelial Inclusions

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The article discusses a rare variant of Solitary Fibrous Tumor (SFT) characterized by extensive epithelial inclusions in abdominopelvic sites, presenting clinicopathologic and molecular findings from three cases. These tumors can mimic biphasic neoplasms composed of epithelial and stromal elements, leading to potential diagnostic challenges for pathologists. The study highlights the importance of using immunohistochemical markers like STAT6 and CD34, along with molecular testing for NAB2-STAT6 fusion, to aid in accurate diagnosis. The tumors showed different histologic features, gene fusions, and prognostic scores, with one case having an aggressive clinical course. The document emphasized the significance of recognizing the morphologic diversity of SFT with epithelial inclusions and distinguishing them from mimicking entities like synovial sarcoma, Mullerian adenosarcoma, and stromal tumors of uncertain malignant potential. Molecular genetic features like NAB2-STAT6 fusions were identified in all cases, aiding in characterizing this rare variant. The article contributes to enhancing awareness among pathologists regarding SFT with extensive epithelial inclusions and the importance of utilizing appropriate diagnostic tools for accurate differentiation from other tumors.

Keywords

Solitary Fibrous Tumor

SFT variant

Epithelial inclusions

Abdominopelvic sites

Clinicopathologic findings

Molecular findings

Immunohistochemical markers

NAB2-STAT6 fusion

Morphologic diversity

Diagnostic tools