AJSP2303 - CME/CMLE - Volumetric Tissue Imaging of Surgical Tissue Specimens Using Micro–Computed Tomography: An Emerging Digital Pathology Modality for Nondestructive, Slide-Free Microscopy—Clinical Applications of Digital Pathology in 3 Dimensions-Volumetric Tissue Imaging of Surgical Tissue Specimens Using Micro–Computed Tomography: An Emerging Digital Pathology Modality for Nondestructive, Slide-Free Microscopy—Clinical Applications of Digital Pathology in 3 Dimensions

Volumetric Tissue Imaging of Surgical Tissue Specimens Using Micro–Computed Tomography: An Emerging Digital Pathology Modality for Nondestructive, Slide-Free Microscopy—Clinical Applications of Digital Pathology in 3 Dimensions

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The document explores the clinical applications of micro-computed tomography (micro-CT) for soft tissue imaging in pathology, focusing on benefits like accurate volumetric measurements and microscopic resolution evaluations of surgical specimens. It reviews 141 articles from 2000 to 2021 showcasing increased use of micro-CT in fields like pulmonology, cardiology, oncology, and forensics, discussing regulatory and financial aspects and potential applications including surgical margin assessment and forensic investigations. Challenges like radiation exposure and contrast sensitivity are addressed alongside solutions and the importance of standardization through DICOM. The study highlights the role of micro-CT in enhancing diagnostic capabilities and treatment planning across medical specialties. The use of micro-CT for various clinical applications, technological advancements, need for image standardization, integration with digital pathology, and the development of quantitative imaging biomarkers are also discussed, emphasizing its significance in refining diagnostic techniques and advancing research methodologies.

Keywords

micro-computed tomography

soft tissue imaging

pathology

volumetric measurements

microscopic resolution evaluations

surgical specimens

pulmonology

cardiology

oncology

forensics