AJSP2306 - CME/CMLE - Multinucleated tumor cells in clear cell renal cell carcinoma-Multinucleated tumor cells in clear cell renal cell carcinoma

Multinucleated tumor cells in clear cell renal cell carcinoma

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The study explores the presence and impact of multinucleated tumor cells (MTCs) in clear cell renal cell carcinoma (ccRCC). The research classified MTC into MTCD, MTCNA, and MTCA and compared their clinicopathologic characteristics and outcomes in ccRCC cases. The study found that while MTCD did not affect patient survival or tumor grading, MTCNA and MTCA were associated with larger tumors, advanced stages, higher nuclear grades, and increased metastatic potential. MTCA cases had a higher rate of recurrence, metastasis, and shorter time to metastasis. Univariate and multivariate analyses revealed MTCA as a significant predictor of adverse outcomes at 5 years. The presence of MTCNA also increased the risk of metastasis. Different MTC types in ccRCC indicate varying survival outcomes, highlighting the need for thorough evaluation and further clarification of MTC inclusion in grading systems. The study recommends a liberal sampling approach to ensure the detection of MTCs in ccRCC for accurate prognosis. Limitations include the small single-institution cohort and the need for detailed quantification methods for validation. Future studies should investigate the etiology of degenerative changes in MTC and consider larger multi-institutional evaluations. Overall, understanding the diverse MTC types in ccRCC is essential for predicting patient outcomes and refining grading systems.

Keywords

multinucleated tumor cells

MTC

clear cell renal cell carcinoma

ccRCC

MTCD

MTCNA

MTCA

clinicopathologic characteristics

metastatic potential

adverse outcomes