APIH223885222 - CME/CMLE - Blood Cell ID #2 - Peripheral Blood Cells in a Normal Patient-APIH223885222

APIH223885222 - Educational Activity

Pdf Summary

The provided educational commentary by Karen A. Brown, MS, MASCP, MLS (ASCP)CM, is intended for medical laboratory sciences professionals, particularly those involved in peripheral blood smear analysis. The document, affiliated with the American Society for Clinical Pathology (ASCP) through the American Proficiency Institute's 2022 2nd Test Event, offers a detailed morphological assessment of peripheral blood cells in a healthy 25-year-old male patient.<br /><br />The Complete Blood Count (CBC) results indicated normal ranges with specific values for white blood cells (WBC), red blood cells (RBC), hemoglobin (Hgb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelets, and red cell distribution width (RDW).<br /><br />Key learning outcomes for participants include:<br />- Identifying morphologic features of normal white blood cells.<br />- Discussing morphologic attributes of normal red blood cells.<br />- Describing the morphology of normal platelets.<br /><br />The commentary elaborates on detailed image analyses:<br />1. Eosinophils: Identified by their large, uniform red-orange granules and typically two-lobed nuclei.<br />2. Platelets: Described with a focus on differentiating them from intracellular inclusions in RBCs. They are small, granular with possible central granulomere, and differ in staining and focusing characteristics from RBC inclusions.<br />3. Normal RBCs: Round, biconcave discs, stain red with an area of central pallor, essential for oxygen transport due to their morphology.<br />4. Monocytes: Largest cells in peripheral blood, characterized by blue-gray rough cytoplasm, sometimes with vacuoles or azurophilic granules, and typically indented or kidney-shaped nuclei.<br />5. Segmented Neutrophils: Identified by their segmented nuclei (2-5 lobes), with pink, tan, or violet small granules.<br /><br />The commentary emphasizes thorough and systematic examination of smears to avoid misinterpretations, as illustrated with the platelet superimposed on an RBC. References for further reading were provided, enhancing the educational value for participants aiming for proficiency in blood cell morphology assessment.

Keywords

medical laboratory sciences

peripheral blood smear

morphological assessment

Complete Blood Count

white blood cells

red blood cells

platelets

eosinophils

monocytes

segmented neutrophils