LQCL2204 - CMLE - B-CELL PHENOTYPE ANALYSIS: WHEN TO ORDER AND WHY-B-CELL PHENOTYPE ANALYSIS: WHEN TO ORDER AND WHY

B-CELL PHENOTYPE ANALYSIS: WHEN TO ORDER AND WHY

Pdf Summary

The document discusses the significance of B-cell phenotyping in clinical immunology, particularly in assessing immune deficiencies and monitoring response to therapies. It outlines the stages of B-cell development, common surface markers for B-cell phenotyping, and the utility of such analysis in various clinical scenarios. B-cell phenotyping helps evaluate inborn errors of immunity, B-cell reconstitution post-HSCT, and response to B cell-depleting therapies like rituximab. Monitoring B-cell subsets assists in diagnosing immune defects and predicting outcomes post-treatment. The text also addresses the challenges in analyzing B-cell subpopulations, emphasizing the need for adequate B-cell numbers for accurate assessment. The importance of communication between clinicians and laboratory scientists is highlighted for effective utilization of comprehensive B-cell phenotyping in patient care. Key points include the impact of rituximab on B-cell levels, monitoring B cells following HSCT for GVHD, and the role of B-cell phenotyping in identifying abnormal B-cell phenotypes post-therapy. Overall, the document stresses the critical role of B-cell phenotyping in diagnosing and managing immune-related disorders.

Keywords

B-cell phenotyping

clinical immunology

immune deficiencies

response to therapies

B-cell development

surface markers

inborn errors of immunity

B-cell reconstitution

rituximab therapy

immune defects