LQCL2301 - CMLE - MANAGEMENT OF VISCOUS SAMPLES IN THE CHEMISTRY LABORATORY: CAUSES, CHALLENGES, AND STRATEGIES FOR TESTING-MANAGEMENT OF VISCOUS SAMPLES IN THE CHEMISTRY LABORATORY: CAUSES, CHALLENGES, AND STRATEGIES FOR TESTING

MANAGEMENT OF VISCOUS SAMPLES IN THE CHEMISTRY LABORATORY: CAUSES, CHALLENGES, AND STRATEGIES FOR TESTING

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A 78-year-old woman with a history of rheumatologic disease presented with symptoms attributed to hyperviscosity syndrome due to elevated serum protein levels. This case study highlights the challenges laboratories face when processing hyperviscous samples and the need for strategies to manage such samples effectively. The inability of the analyzer to aspirate the serum sample was attributed to its viscous nature, commonly caused by conditions like multiple myeloma or cryoglobulinemia.<br /><br />The presence of paraproteins in the sample led to interference with laboratory measurements, affecting tests like serum albumin and electrolyte levels. Various interventions can help mitigate such interferences, including dilution techniques and using specialized analyzers like direct ion-selective electrodes.<br /><br />The patient was successfully treated with plasmapheresis after confirming the presence of M protein and resolving her symptoms. Laboratory professionals play a crucial role in promptly communicating findings of hyperviscosity syndrome to clinicians, guiding diagnosis and treatment decisions to prevent irreversible organ damage.<br /><br />Understanding the complexities of handling hyperviscous samples and implementing appropriate protocols is essential for accurate laboratory testing and patient care. The case underlines the importance of tailored management strategies for challenging sample types in clinical settings.

Keywords

rheumatologic disease

hyperviscosity syndrome

elevated serum protein levels

multiple myeloma

cryoglobulinemia

paraproteins

serum albumin

electrolyte levels

plasmapheresis

M protein