LQCL2302 - CMLE - Falsely Elevated Troponin Results-Falsely Elevated Troponin Results

Falsely Elevated Troponin Results

Pdf Summary

The document discusses a case involving a 35-year-old man with elevated cardiac troponin levels but no acute myocardial infarction. The aim is to investigate the cause of the discrepancy between the clinical and laboratory findings, with a focus on immunoassay interferences. Several possible interferences are highlighted, including hemolysis, icterus, interfering antibodies, and macroproteins. Techniques like protein precipitation or gel filtration chromatography can help to identify and investigate macroprotein interference. The importance of interpreting troponin results accurately for diagnosing myocardial infarction is emphasized, with considerations for chronic elevations unrelated to acute events. The case study demonstrated the need for a systematic approach to investigate and resolve issues with troponin assays, ultimately highlighting the significance of accurate laboratory testing for patient care.

Keywords

cardiac troponin levels

acute myocardial infarction

immunoassay interferences

hemolysis

icterus

interfering antibodies

macroproteins

protein precipitation

gel filtration chromatography

troponin assays