LQCL2307 - CMLE - ATYPICAL LYMPHOCYTOSIS IN AN ADULT PATIENT WITH T-CELL PROLYMPHOCYTIC LEUKEMIA-ATYPICAL LYMPHOCYTOSIS IN AN ADULT PATIENT WITH T-CELL PROLYMPHOCYTIC LEUKEMIA

ATYPICAL LYMPHOCYTOSIS IN AN ADULT PATIENT WITH T-CELL PROLYMPHOCYTIC LEUKEMIA

Pdf Summary

T-cell prolymphocytic leukemia (T-PLL) is a rare but aggressive T-cell neoplasm that mainly affects older individuals, often presenting with symptoms like fatigue, weight loss, and night sweats. Diagnosis involves identifying characteristic morphologic, immunophenotypic, and cytogenetic features, including expression of CD7 and CD26. Treatment options include chemotherapy and anti-CD52 therapy, with poor response rates and a short median survival time. Differential diagnosis includes other mature T-cell lymphomas. Recognition of hyperlymphocytosis in blood samples is crucial for diagnosis. Serologic testing for HTLV-1 is essential for ruling out other conditions. T-PLL cases often involve genetic abnormalities such as t(X;14) rearrangements. Overall, a comprehensive evaluation is necessary to differentiate T-PLL from other T-cell disorders and initiate appropriate treatment strategies.

Keywords

T-cell prolymphocytic leukemia

T-PLL

T-cell neoplasm

CD7

CD26

chemotherapy

anti-CD52 therapy

hyperlymphocytosis

HTLV-1

t(X;14) rearrangements