LQCL2309 - CMLE - Acute Promyelocytic Leukemia, Microgranular Variant-Acute Promyelocytic Leukemia, Microgranular Variant

Acute Promyelocytic Leukemia, Microgranular Variant

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The document discusses a case study of a 24-year-old man presenting with symptoms leading to a diagnosis of acute promyelocytic leukemia (APL), specifically the microgranular variant. The document outlines the importance of recognizing this rare variant of APL, characterized by the absence of typical granules in neoplastic promyelocytes. It emphasizes the significance of prompt diagnosis and treatment initiation to prevent life-threatening bleeding from coagulopathy. Diagnostic tools such as blood smear review, flow cytometry, and FISH for PML::RARA fusion are essential in confirming the diagnosis. Treatment involves all-trans retinoic acid and chemotherapy, with a favorable prognosis if managed promptly. The document also highlights the differential diagnosis and molecular studies involved in confirming APL, as well as monitoring residual disease post-consolidation therapy. The case underscores the importance of early recognition and appropriate management for successful outcomes in APL patients, marking it as a critical medical emergency in hematology.

Keywords

24-year-old man

acute promyelocytic leukemia

microgranular variant

neoplastic promyelocytes

coagulopathy

diagnostic tools

PML::RARA fusion

all-trans retinoic acid

chemotherapy

residual disease post-consolidation therapy