LQCL2314 - CMLE - The Role of the Laboratory in Guiding Cancer Treatment Planning-The Role of the Laboratory in Guiding Cancer Treatment Planning

The Role of the Laboratory in Guiding Cancer Treatment Planning

Pdf Summary

The document discusses the role of molecular diagnostics in guiding cancer treatment decisions, focusing on a case study of a woman with mucoepidermoid carcinoma and subsequent metastatic disease. It emphasizes the importance of tumor marker panels in determining targeted therapies, such as small-molecule drugs and monoclonal antibodies. These therapies specifically target cancer cells while minimizing side effects compared to conventional chemotherapy. The document highlights the pros and cons of targeted therapy, including the need for pre-administrative evaluation for targetable molecules and the development of drug resistance. It also addresses the challenges of drug development and the high costs associated with targeted therapy. The conclusion of the case study shows successful treatment with gefitinib targeting the EGFR mutation. The document emphasizes the evolving role of pathology laboratories in personalized medicine and targeted therapy, recognizing their vital role in cancer treatment planning.

Keywords

molecular diagnostics

cancer treatment decisions

tumor marker panels

targeted therapies

small-molecule drugs

monoclonal antibodies

drug resistance

targetable molecules

EGFR mutation

personalized medicine