LQCL2317 - CMLE - AN AMBIGUOUS CASE OF FETOMATERNAL HEMORRHAGE WITH STRONG KLEIHAUER-BETKE POSITIVITY-AN AMBIGUOUS CASE OF FETOMATERNAL HEMORRHAGE WITH STRONG KLEIHAUER-BETKE POSITIVITY

AN AMBIGUOUS CASE OF FETOMATERNAL HEMORRHAGE WITH STRONG KLEIHAUER-BETKE POSITIVITY

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Transfusion medicine plays a crucial role in managing complications related to blood type incompatibilities during pregnancy. This document discusses a case of a pregnant Rh-negative woman carrying an Rh-positive fetus, where a Kleihauer-Betke test (KBT) indicated a significant fetal blood presence. The text emphasizes the importance of accurately quantifying fetomaternal hemorrhage (FMH) to determine the appropriate dosage of Rh immune globulin (RhIg) to prevent immunization. It highlights the challenges in interpreting test results, such as false positives/negatives, and the need for confirmatory tests like flow cytometry in certain cases. The complexity of administering RhIg, including dosages and potential adverse effects, is also addressed. Adverse reactions to RhIg are generally mild, but precautions must be taken, especially in diabetic patients. The text also touches on the importance of proper documentation and handling of deviations in medication regimens to ensure patient safety. Overall, the document underscores the significance of accurate testing, appropriate dosing, and vigilance in managing potential complications associated with FMH and blood type incompatibilities during pregnancy.

Keywords

transfusion medicine

blood type incompatibilities

pregnancy complications

Rh-negative

Rh-positive fetus

Kleihauer-Betke test

fetomaternal hemorrhage

Rh immune globulin

flow cytometry

adverse reactions