LQCL2405 - CMLE - Cytokine Testing – Know Your Assays!-Cytokine Testing

Cytokine Testing – Know Your Assays!

Pdf Summary

The document discusses the importance of analyzing cytokines in clinical practice, particularly in the context of cytokine-targeting therapies and monitoring adverse events. It describes the functions of cytokines, types of assays for cytokine measurement, and the significance of using the same laboratory and assay for accurate results. A case study of a baby with familial hemophagocytic lymphohistiocytosis is used to demonstrate the clinical application of cytokine testing. Various cytokine-targeting biologics are listed, such as those targeting TNF-α, interleukins, and interferons. Cytokines play a crucial role in immune responses and are classified based on their function, type of immune response, and T cell type. Different assays like ELISA and bead multiplex are used for cytokine measurement, each with its own advantages and limitations. The document emphasizes the need for consistency in assays and platforms for accurate monitoring of cytokine levels, especially when assessing response to therapy. It also highlights the challenges and variability in cytokine analysis across different laboratories and platforms, underscoring the importance of standardization for reliable clinical interpretation of results.

Keywords

cytokines analysis

clinical practice

cytokine-targeting therapies

adverse events monitoring

cytokine functions

assays for cytokine measurement

laboratory consistency

cytokine testing case study

cytokine-targeting biologics

immune response classification