LQCL2409 - CMLE - Plasma Cell Leukemia-Plasma Cell Leukemia

Plasma Cell Leukemia

Pdf Summary

The document discusses a case study of a 72-year-old woman with plasma cell myeloma who developed plasma cell leukemia (PCL). The patient presented with systemic symptoms and abnormal laboratory values, including elevated M-protein and free lambda light chain, decreased glomerular filtration rate, and anemia. Peripheral blood and bone marrow analysis revealed abnormal plasma cells with cytogenetic abnormalities. PCL was diagnosed based on the presence of circulating plasma cells. The document elaborates on the clinical features, diagnosis, immunophenotypic characteristics, and prognosis of PCL compared to multiple myeloma. It also highlights the treatment options for PCL, emphasizing the urgency of disease control. The case study underscores the importance of accurate morphologic examination in diagnosing PCL and the challenges in managing this aggressive plasma cell disorder. The document concludes with references and a set of multiple-choice questions related to PCL diagnosis and characteristics.

Keywords

plasma cell myeloma

plasma cell leukemia

PCL diagnosis

immunophenotypic characteristics

cytogenetic abnormalities

treatment options

multiple myeloma comparison

clinical features

prognosis

morphologic examination