LQCL2418 - CMLE - Fetal/Neonatal Alloimmune Thrombocytopenia: When You Are Just Like Your Father-Fetal/Neonatal Alloimmune Thrombocytopenia: When You Are Just Like Your Father

Fetal/Neonatal Alloimmune Thrombocytopenia: When You Are Just Like Your Father

Pdf Summary

The document discusses Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT), a condition where maternal antibodies attack fetal platelets, causing thrombocytopenia. It covers symptoms, prevalence, diagnosis, and treatment of FNAIT, focusing on a case of a 2-day-old neonate with low platelet count. Laboratory tests confirmed FNAIT due to antibodies targeting platelet antigen HPA-1a. Treatment included platelet transfusions and IVIG to prevent bleeding. Genetic testing revealed paternal HPA-1a positivity, indicating future pregnancy risks. Challenges in screening for FNAIT include lack of consensus on management and prophylactic treatments. The importance of early diagnosis and tailored treatment to prevent severe outcomes like intracranial hemorrhage is emphasized. Genotyping, platelet transfusions, and IVIG are key aspects of FNAIT management. The document also notes the controversies in HLA antibody's role in FNAIT and the varying impacts of different HPA antibodies in diverse populations. Additionally, it includes multiple-choice questions testing knowledge of FNAIT symptoms, diagnostic tests, treatment strategies, and genetic factors influencing the condition.

Keywords

Fetal/Neonatal Alloimmune Thrombocytopenia

FNAIT

maternal antibodies

platelet antigen HPA-1a

low platelet count

IVIG treatment

genetic testing

intracranial hemorrhage

HLA antibody

platelet transfusions