LQHS2203 - CMLE - SOLID TUMOR TISSUE SELECTION FOR MOLECULAR TESTING-SOLID TUMOR TISSUE SELECTION FOR MOLECULAR TESTING

SOLID TUMOR TISSUE SELECTION FOR MOLECULAR TESTING

Pdf Summary

The document discusses the importance of tissue selection for molecular testing in a case of non-small cell lung carcinoma. A 45-year-old man presented with symptoms and was found to have advanced-stage lung cancer. Molecular testing for targeted therapies was ordered, necessitating careful tissue selection. Various factors are highlighted, including tissue considerations, requirements, and testing strategies. The importance of tumor percentage, cellularity, and preanalytic variables such as fixatives and artifacts is emphasized. The document also includes a case conclusion where an actionable alteration was identified, enabling targeted therapy for the patient. Key points discussed in the document include tissue sources, fixatives, optimal tumor percentage, and potential inhibitors impacting molecular testing. The significance of proper tissue selection techniques from solid tumor specimens is highlighted to ensure successful molecular results. In conclusion, following appropriate methods for tissue selection when conducting molecular analysis is crucial for accurate diagnosis and treatment decisions in cancer patients.

Keywords

tissue selection

molecular testing

non-small cell lung carcinoma

targeted therapies

tumor percentage

cellularity

preanalytic variables

fixatives

solid tumor specimens

cancer patients