LQHS2301 - CMLE - EVALUATING THE ADEQUACY OF TRANSPLANT KIDNEY BIOPSIES-EVALUATING THE ADEQUACY OF TRANSPLANT KIDNEY BIOPSIES

EVALUATING THE ADEQUACY OF TRANSPLANT KIDNEY BIOPSIES

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The document discusses the importance of evaluating kidney biopsies using light microscopy, immunofluorescence, and electron microscopy. It highlights the necessity of examining the medulla in addition to the cortex for certain conditions affecting the kidney, such as BK nephropathy. In a case study of a 49-year-old male kidney transplant recipient with rising creatinine levels, a kidney biopsy was performed. The initial biopsy sample only contained renal cortex, necessitating a second core for adequate medulla sampling. The histological evaluation revealed tubulointerstitial inflammation consistent with BK nephropathy. Effective communication between nephrologists and pathologists is crucial for proper triage and diagnosis of renal biopsies. The document emphasizes the significance of understanding the clinical indications and differential diagnoses for kidney biopsies to ensure accurate evaluation. Additionally, it provides CMLE questions to test understanding of the material covered in the document.

Keywords

kidney biopsies

light microscopy

immunofluorescence

electron microscopy

medulla

cortex

BK nephropathy

tubulointerstitial inflammation

nephrologists

pathologists