LQHS2302 - CMLE - A WILMS TUMOR (NEPHROBLASTOMA) IN THE GROSS ROOM-A WILMS TUMOR (NEPHROBLASTOMA) IN THE GROSS ROOM

A WILMS TUMOR (NEPHROBLASTOMA) IN THE GROSS ROOM

Pdf Summary

The document discusses a case of a 4-year-old girl who presented with an abdominal mass that was later diagnosed as Wilms tumor, a rare kidney tumor in children. The text outlines the importance of identifying syndromes associated with higher Wilms tumor risk, the role of molecular testing in managing the tumor, and the need for appropriate tissue submission for diagnosis and risk assessment. The specimen from the nephrectomy was analyzed for triphasic histology, particularly anaplasia, which impacts prognosis and treatment. The document emphasizes meticulous handling and documentation of specimens during gross dissection, including the need for fresh tissue for molecular studies. Detailed macroscopic photography, snap-freezing of tumor for banking, and proper sampling for permanent sections are highlighted for accurate staging and treatment decisions. In this specific case, the tumor was diagnosed as a classic Wilms tumor with favorable histology and localized stage II. Molecular testing classified the tumor as low risk, guiding the choice of therapy. The overall summary underscores the crucial role of medical laboratory professionals in contributing to the accurate diagnosis and treatment planning for patients with Wilms tumor.

Keywords

4-year-old girl

abdominal mass

Wilms tumor

rare kidney tumor

molecular testing

triaphasic histology

anaplasia

specimen analysis

tissue submission

treatment decisions