AJMP2504 - CME/CMLE - Revision of interpretation criteria to define microsatellite instability in mismatch repair deficient neoplasms with subtle electropherogram changes

Course Description

Faculty/Authors
Melissa P. Upton, MD
Department of Pathology, University of Washington, Seattle

CME/CMLE Credit: 1.0
Estimated Completion Time: 1 hour
Format: Online Educational Activity and Post-Test

Physician Competencies:Medical knowledge, patient care, practice-based learning

Eligibility for CME/CMLE credit: Max three attempts. You will have a maximum of three attempts to meet the following criteria:

Module ≥80% = CME credit
Module <80% = No CME credit, after a maximum of three attempts

Default Credit Type: None (You must meet the eligibility requirements in order to obtain CME or SAMs CME credit.)

Accreditation Statement: The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME).

Credit Designation Statement: The American Society for Clinical Pathology (ASCP) designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions

To claim CME/CMLE credit for the exercise, do the following:

Review the Technical Considerations.
Click Go to Course to view an overview of the modules in this course.
Click Access to begin the course.
Review the Educational Activity.
Complete and submit the Post-Test. You will have a maximum of three attempts to obtain the required score. You will be notified if you have met the credit requirements after each attempt.
Submit the course Evaluation to register your credit.

Faculty Disclosures
The Journal CME editor and faculty have no relevant financial relationships with commercial interests to disclose.

Technical Considerations

Release Date: 5/23/2025
Review Date:
Expiration Date: 5/23/2028

Course Objectives

Following completion of this activity, you will be able to:

Summarize the rationale for using mononucleotide microsatellite loci rather than nucleotide microsatellite loci when performing assays to detect microsatellite instability (MSI).

Outline the recommendations for MSI testing published in the guideline of the College of American Pathologists that was endorsed by the American Society of Clinical Oncology.

Describe the efficacy and the limitations of the revised criteria of MSI as defined by the authors in this paper.

Summary

Availability:

On-Demand

Credit Offered:

1 CME/CMLE Credit