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AJSP2603 - CMLE - AJCP CME: Building a diagnostic scoring system for high-grade neuroendocrine neoplasms of the pancreas
Course Description

This AJCP article offers 1.0 continuing education (CME) credit that can be used to fulfill CC Part II requirements. Purchase of this CME activity provides gratis access to a PDF of the journal article for the learner’s personal use only. 

Upon completion of this activity, learners will be able to: 

  1. Summarize the treatment differences between high-grade pancreatic neuroendocrine tumors (PanNET3) and poorly differentiated neuroendocrine carcinomas (PanNECs) that necessitate diagnostic differentiation between these types of high-grade pancreatic neuroendocrine neoplasms (PanNENs).  

  1. List diagnostic histomorphological, immunohistochemical, and molecular features that can assist in differentiating PanNET3 from PanNEC. 

  1. Discuss biological implications of the immunohistochemical and molecular features of PanNET3 and PanNEC.  

 

Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants 

 

Faculty/Authors
Melissa P. Upton, MD

CME/CMLE Credit: 1.0
Estimated Completion Time: 1 hour
Format: Online Educational Activity and Post-Test

Physician Competencies: Medical knowledge, patient care, practice-based learning

Eligibility for CME/CMLE credit: Max three attempts. You will have a maximum of three attempts to meet the following criteria:

  • Module ≥80% = CME credit
  • Module <80% = No CME credit, after a maximum of three attempts

Default Credit Type: None (You must meet the eligibility requirements in order to obtain CME or SAMs CME credit.)

Accreditation Statement: The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME).

Credit Designation Statement: The American Society for Clinical Pathology (ASCP) designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions

To claim CME/CMLE credit for the exercise, do the following:

  1. Review the Technical Considerations.
  2. Click Go to Course to view an overview of the modules in this course.
  3. Click Access to begin the course.
  4. Review the Educational Activity.
  5. Complete and submit the Post-Test. You will have a maximum of three attempts to obtain the required score. You will be notified if you have met the credit requirements after each attempt.
  6. Submit the course Evaluation to register your credit.

Faculty Disclosures​
The Journal CME editor and faculty have no relevant financial relationships with commercial interests to disclose.

Technical Considerations

Release Date: 3/30/2026  
Review Date:
Expiration Date: 3/30/2029   

Course Objectives
Following completion of this activity, you will be able to:

  1. Summarize the treatment differences between high-grade pancreatic neuroendocrine tumors (PanNET3) and poorly differentiated neuroendocrine carcinomas (PanNECs) that necessitate diagnostic differentiation between these types of high-grade pancreatic neuroendocrine neoplasms (PanNENs).  

  1. List diagnostic histomorphological, immunohistochemical, and molecular features that can assist in differentiating PanNET3 from PanNEC. 

  1. Discuss biological implications of the immunohistochemical and molecular features of PanNET3 and PanNEC.  
Summary
Availability:
On-Demand
Credit Offered:
1 CME/CMLE Credit
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