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CSHP2602 - CME/CMLE - Cyclin D1–Positive Diffuse Large B-Cell Lymphoma Arising from Atypical Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Diagnostic Pitfall
Course Description

Faculty/Authors

Naijia Liu, MD
Iris Ma
Yang Shi, MD, PhD

Department of Pathology and Laboratory
Montefiore Medical Center
New York, New York 

CME or CMLE Credit: 2.0
Estimated Completion Time: 2 hours
Format: Online Educational Activity and Post Exam

Physician Competencies: Patient Care, Medical Knowledge, Practice-Based Learning and Improvement; Systems-Based Practice

Eligibility for CME/CMLE credit: Max three attempts. You will have a maximum of three attempts to meet the following criteria:

  • Module ≥80% = CME credit
  • Module <80% = No CME credit, after a maximum of three attempts

Default Credit Type: None (You must meet the eligibility requirements in order to obtain CME credit.)

Accreditation Statement: The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME).

Credit Designation Statement: The American Society for Clinical Pathology (ASCP) designates this enduring material for a maximum of 2 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions

  1. Review the Technical Considerations.
  2. Click Go to Course to view an overview of the modules in this course.
  3. Click Access to begin the course.
  4. Choose the CME Activity to earn CME credit or the CMLE Activity to earn CMLE credit.

To claim CME credit for the exercise, do the following:

  1. Review the Educational Activity.
  2. Complete and submit the Post Exam. You will have a maximum of three attempts to obtain the required score. You will be notified if you have met the credit requirements after each attempt.
  3. Submit the course Evaluation.
  4. Enter the maximum number of credits offered and click Claim CME to register credit.

To claim CMLE credit for the exercise, do the following:

  1. Review the Educational Activity.
  2. Complete and submit the Post Exam.
  3. Submit the course Evaluation.
  4. Enter the maximum number of credits offered and click Claim CME to register credit.

Faculty Disclosures

Technical Considerations

Release Date: 4/30/2026  
Review Date:
Expiration Date: 12/31/2028 

Learning Objectives
Upon completion of this activity, you will be able to:

  • understand the morphologic, immunophenotypic, and genetic features of cyclin D1–positive diffuse large B cell lymphoma; 

  • identify the various morphological variants of mantle cell lymphoma, including blastoid, pleomorphic, small cell, marginal zone–like, and leukemic non-nodal mantle cell lymphoma (nnMCL); 

  • recognize the key immunophenotypic and genetic characteristics associated with mantle cell lymphoma; 

  • distinguish between blastoid/pleomorphic variants of mantle cell lymphoma and cyclin D1–positive diffuse large B-cell lymphoma in the differential diagnosis; and 

  • understand the differential diagnosis of CD5-positive small B-cell lymphomas, with emphasis on distinguishing chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, CD5-positive marginal zone lymphoma, and CD5-positive lymphoplasmacytic lymphoma. 

 
 
Summary
Availability:
On-Demand
Credit Offered:
2 CME Credits
2 CMLE Credits
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