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  2. CSRP2506 - CME/CMLE - Fabry Nephropathy
CSRP2506 - CME/CMLE - Fabry Nephropathy
Course Description

Faculty/Authors

Meghan E. Kapp, MD
Morvarid Elahi, MD 
Sara Akhavanfard, MD, PhD
Jessica Sigel, MD
University Hospitals Cleveland Medical Center
Case Western Reserve University
Cleveland, Ohio 

CME or CMLE Credit: 2.0

Estimated Completion Time: 2 hours
Format: Online Educational Activity and Post Exam

Physician Competencies: Patient Care, Medical Knowledge

Eligibility for CME/CMLE credit: Max three attempts. You will have a maximum of three attempts to meet the following criteria:

 
  • Module ≥80% = CME credit
  • Module <80% = No CME credit, after a maximum of three attempts

Default Credit Type: None (You must meet the eligibility requirements in order to obtain CME credit.)

Accreditation Statement: The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME).

Credit Designation Statement: The American Society for Clinical Pathology (ASCP) designates this enduring material for a maximum of 2 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions

  1. Review the Technical Considerations.
  2. Click Go to Course to view an overview of the modules in this course.
  3. Click Access to begin the course.
  4. Choose the CME Activity to earn CME credit or the CMLE Activity to earn CMLE credit.

To claim CME credit for the exercise, do the following:

  1. Review the Educational Activity.
  2. Complete and submit the Post Exam. You will have a maximum of three attempts to obtain the required score. You will be notified if you have met the credit requirements after each attempt.
  3. Submit the course Evaluation.
  4. Enter the maximum number of credits offered and click Claim CME to register credit.

To claim CMLE credit for the exercise, do the following:

  1. Review the Educational Activity.
  2. Complete and submit the Post Exam.
  3. Submit the course Evaluation.
  4. Enter the maximum number of credits offered and click Claim CME to register credit.

Faculty Disclosures

Technical Considerations

Release Date: 12/31/2025    
Review Date:
Expiration Date: 12/31/2027   

Learning Objectives
Upon completion of this activity, you will be able to:

  • describe the pathophysiology of Fabry disease, including the role of α-galactosidase A deficiency and globotriaosyceramide (GB3); 

  • identify key diagnostic approaches for Fabry disease, including enzymatic activity assays and genetic testing of the GLA gene; 

  • explain the natural history and pathologic findings of Fabry nephropathy, including early podocyte injury, proteinuria, and characteristic histologic/electron microscopic features (myeloid bodies); 

  • compare and evaluate therapeutic options for Fabry disease, including enyzme replacement therapy (ERT) and chaperone therapy (e.g. migalastat); and 

  • apply case-based knowledge to identify Fabry disease in patients with unexplained chronic kidney disease or hypertrophic cardiomyopathy to avoid diagnostic delays. 

Summary
Availability:
On-Demand
Credit Offered:
2 CME Credits
2 CMLE Credits
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