Osteosarcoma and Ewing sarcoma are common pediatric malignant bone tumors, however, histologic mimickers can make their diagnosis challenging on small biopsies. In the last decade, molecular signatures, their immunohistochemical surrogates and novel histone markers have emerged to be useful diagnostic adjuncts that can improve the diagnostic yield of a small biopsy. Benign tumors are typically treated by local curettage, often completed following a frozen section diagnosis while malignant tumors initiate an oncology referral accompanied by a wide excision with emphasis on negative margins. An accurate malignant diagnosis facilitates timely enrollment in treatment protocols that can be specific to tumor types. Since bone tumors are typically biopsied at presentation, they may be evaluated by pathologists in community practice as well as academic pathologists. This education session will focus on familiarizing trainees and practicing pathologists on the biopsy interpretation of pediatric bone tumors, pertinent differential diagnoses, pitfalls and the cost-effective work-up of biopsies.

Faculty/Authors

Archana Shenoy, MD, FASCP
John D. Reith, MD, FASCP

Physician Competencies: Patient Care, Medical Knowledge, Professionalism, Interpersonal Skills Communication

CME/CMLE Credit: 1.0
Estimated Completion Time: 1 hour
Format: Online Educational Activity

Accreditation Statement: The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME).

Credit Designation Statement: The American Society for Clinical Pathology (ASCP) designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions

To claim CME/CMLE credit for the exercise, do the following:

1. Review the Technical Considerations.
2. Review the Faculty Disclosures.
3. Click Go to Course to view an overview of the modules in this course.
4. Click Access to begin the course.
5. Submit the course Evaluation.
6. Enter the maximum number of credits offered and click Claim CME to register credit.

Faculty Disclosure

Technical Considerations

Release Date: 08/19/2022
Review Date:
Expiration Date: 03/06/2025