Emerging Biomarkers in the Assessment of Alzheimer’s Disease
 
This activity is designed to introduce pathologists, laboratory managers/directors, and laboratory professionals to emerging research in biomarker testing (cerebral spinal fluid [CSF] and blood-based biomarkers) and imaging for the detection of Alzheimer’s disease. You will learn about the biological significance and the clinical implications of these biomarkers, as well as how to utilize the AT(N) framework for Alzheimer’s disease diagnosis and biomarker classification. Additionally, you will also learn about the limitations of current biomarkers for Alzheimer’s disease and directions for future research.

Faculty/Authors
S.-H. Jerry Wang, MD, PhD
Assistant Professor of Pathology and Neurology
Duke/UNC ADRC Neuropathology Core Leader
Director, Duke Bryan Brain Bank
Associate Director, Autopsy Neuropathology
Duke University Medical Center 

Target Audience
This activity has been designed to meet the educational needs of pathologists, laboratory managers/directors, and laboratory professionals 
 
Accreditation Statement
The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians.

Physician's Competency: Patient Care, Medical Knowledge.

CME/CMLE Credit: 1.0
Estimated Completion Time: 1.0 hour
Format: Online educational activity

Credit Designation Statement
The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians.
 
The ASCP designates this activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.
 
ASCP designates this activity for a maximum of 0.5 CMLE credit.  This activity meets CMP and state re-licensure requirements for laboratory personnel.
 
For questions regarding CME credit, please contact ASCP Customer Service at 1-800-267-2727, during normal business hours: Monday through Friday, 8 a.m. to 6 p.m. Eastern Time

Method of Participation
To complete the activity and receive credit, the participant must complete the online activity. CME certificates will be provided online.
 
Commercial Support
This activity is funded by an independent educational grant from Bristol Myers Squibb.

Instructions

To claim CME/CMLE credit for the exercise, do the following:

1. Review the Technical Considerations.
2. Click Go to Content and click the first module of the course.
3. Complete the Demographic Survey.
4. Complete the Pre-Test.
5. Review the Educational Activity.
6. Complete and submit the Post Exam. You will have a maximum of three attempts to obtain the required score. You will be notified if you have met the credit requirements after each attempt.
7. Submit the course Evaluation.
8. Enter the maximum number of credits offered and click Claim CME/CMLE to register credit.

Upon completion of this activity, you will be able to:

• Discuss advances in body fluid biomarkers and imaging for Alzheimer’s disease, including the biological underpinnings of these biomarkers, clinical implications, limitations, and potential future research and trends

• Utilize the AT(N) framework to classify biomarkers for Alzheimer’s disease