This case-based activity is designed to help pathologists and laboratory professional gain an understanding of the cytologic and histopathological characteristics of HPV-negative cervical cancers and precancers, including with an emphasis on squamous cell carcinomas, adenocarcinomas and their precursors.

Course topics include: 

• Cytologic and histologic features of HPV-negative squamous cell carcinoma and adenocarcinoma 
• Clinical characteristics of HPV-negative versus HPV-associated cervical cancers and pre-cancers 
• Presenting features of HPV-negative versus HPV-associated cervical lesions  

Target Audience 
This activity has been designed to meet the educational needs of pathologists and laboratory professionals.    

Faculty/Authors

Tamar C. Brandler, MD, MS
Associate Professor, Pathology
Director, Division of Cytopathology 
Robert Wood Johnson Medical School
New Brunswick NJ 

Physician's Competency: Patient Care, Medical Knowledge, Practice-Based Learning and Improvement 

CME/CMLE Credit: 0.25
Estimated Completion Time: 0.25 hour
Format: Online educational activity

Accreditation Statement
The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians. 

Credit Designation Statement

The ASCP designates this internet live activity for a maximum of .25 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity. 

ASCP designates this live activity for a maximum of .25 CMLE credit.  This activity meets CMP and state re-licensure requirements for laboratory personnel. 

For questions regarding CME credit, please contact ASCP Customer Service at 1-800-267-2727, option 2, in the US & Canada or internationally at access code + 3-1-312-541-4890. Monday-Friday, 8am-5pm CT.

Method of Participation

To complete the activity and receive credit, the participant must participate in the online program. CME certificates will be provided on-line.  

Commercial Support 

This activity is supported by an independent educational grant from Hologic.   

Instructions

To claim CME/CMLE credit for the exercise, do the following:

1. Review the Technical Considerations.
2. Click Go to Content and click the first module of the course.
3. Complete the Demographic Survey.
4. Complete the Pre-Test.
5. Review the Educational Activity.
6. Complete and submit the Post Exam. You will have a maximum of three attempts to obtain the required score. You will be notified if you have met the credit requirements after each attempt.
7. Submit the course Evaluation.
8. Enter the maximum number of credits offered and click Claim CME/CMLE to register credit.

Upon completion of this activity, you will be able to:

• Recognize cytologic and histologic features of HPV-negative squamous cell carcinoma and adenocarcinoma on gynecologic pap tests and histologic sections 

• Distinguish clinical characteristics of HPV-negative versus HPV-associated cervical cancers and pre-cancers 

• Differentiate presenting features of HPV-negative HPV-associated cervical lesions 

• Identify key ancillary studies in the workup of HPV-negative lesions