Navigating Challenges with PD-L1 Combined Positive Score (CPS)
 
This activity is designed to help pathologists and laboratory professionals learn how PD-L1 testing, and interpretation is performed using the combined positive score (CPS). Panelists will review how CPS is used to determine PD-L1 positivity. They will also describe some of the challenges associated with scoring certain types of cancers using CPS. Panelists will list some practical ways to ensure optimal PD-L1 testing and scoring using CPS.  
Provided by the American Society for Clinical Pathology in partnership with Q Synthesis LLC.
 
The activity offers 0.5 CME/CMLE credit.
 
Target Audience
This activity has been designed to meet the educational needs of pathologists and laboratory professionals diagnosing cancer.
 
Activity Agenda

• Introductions
• Review the definition of combined positive score (CPS)
• Panel discussion: what makes CPS so challenging
• Recommended steps to improve PD-L1 testing and scoring
• Summary of key takeaways

Faculty/Authors

Wei Zhang, MD, PhD   
Assistant Professor, Pathology and Laboratory Medicine 
Medical Director of Molecular Pathology in Solid Tumor, Pathology and Laboratory Medicine 
University of Kansas 
 
Stuti Shroff, MD, PhD   
Assistant Professor of Pathology, Harvard Medical School 
Assistant Pathologist, Anatomic and Molecular Pathology, Massachusetts General Hospital 
 
Lamees Saeed, MD  
Breast and Molecular Pathology Fellow at Moffitt Cancer Center 
 
Joseph Kim, MD  
President of Q Synthesis LLC 

Accreditation Statement
The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians. 

Physician's Competency: Patient Care, Medical Knowledge, Practice-Based Learning and Improvement

CME/CMLE Credit: 0.5
Estimated Completion Time: 0.5 hour
Format: Online educational activity

Credit Designation Statement
The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education (CME) for physicians.
 
The ASCP designates this activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.
 
ASCP designates this activity for a maximum of 0.5 CMLE credit.  This activity meets CMP and state re-licensure requirements for laboratory personnel.
 
For questions regarding CME credit, please contact ASCP Customer Service at 1-800-267-2727, during normal business hours: Monday through Friday, 8 a.m. to 6 p.m. Eastern Time 

Method of Participation
To complete the activity and receive credit, the participant must complete the online activity. CME certificates will be provided onlin 
 
Commercial Support
This activity is funded by an independent educational grant from Merck. 

Instructions

To claim CME/CMLE credit for the exercise, do the following:

1. Review the Technical Considerations.
2. Click Go to Content and click the first module of the course.
3. Complete the Demographic Survey.
4. Complete the Pre-Test.
5. Review the Educational Activity.
6. Complete and submit the Post Exam. You will have a maximum of three attempts to obtain the required score. You will be notified if you have met the credit requirements after each attempt.
7. Submit the course Evaluation.
8. Enter the maximum number of credits offered and click Claim CME/CMLE to register credit.

Upon completion of this activity, you will be able to:

• Describe how PD-L1 expression is determined using combined positive score (CPS).

• Outline some of the challenges pathologists face when using combined positive score (CPS).

• Discuss ways to achieve accurate assessment of PD-L1 protein expression when using combined  positive score (CPS).