LPR109-25 - CME/CMLE - Updates in Cellular Therapies from a Laboratorians’ Perspective

Course Description

The newly approved Gene Therapies for Sickle Cell Disease (SCD) now offers patients an option for a transformative treatment. Generating a gene therapy product requires collecting sufficient CD34+ hematopoietic stem cells from patients and is essential for the successful manufacture of gene therapy products at a therapeutic dose. Patients require up to 50 units of red cells in preparation for collection and to support the transplantation of the gene therapy product. This places a high demand on the blood bank as well as on blood donor services. In this session we will review the workflow surrounding commercial gene therapy for SCD and examine how blood transfusion is used to support stem cell collection and transplant. We will describe the challenges to the blood bank and describe tools, procedures and novel workflows to support gene therapy for SCD. Patients that enter the gene therapy journey are followed by many teams including Hematology, Stem Cell Transplant and Transfusion Medicine. We will review how to communicate blood bank results and blood supply and how to plan for the increased demand for specialized blood products for SCD patients.

This session offers 1.0 CME/CMLE credit.

Faculty/Authors

Manis John

Physician Competencies: Patient Care, Medical Knowledge
CME/CMLE Credit: 1.0
Estimated Completion Time: 1 hour
Format: Online Educational Activity

Accreditation Statement: The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME).

Credit Designation Statement: The American Society for Clinical Pathology (ASCP) designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions

To claim CME/CMLE credit for the exercise, do the following:

Review the Technical Considerations.
Review the Faculty Disclosures.
Click Go to Course to view an overview of the modules in this course.
Click Access to begin the course.
Submit the course Evaluation.
Enter the maximum number of credits offered and click Claim CME to register credit.

Faculty Disclosure

Technical Considerations

Release Date: 11/19/2025
Review Date:
Expiration Date:

Summary

Availability:

On-Demand

Credit Offered:

1 CME/CMLE Credit