LabQ 2023 Clinical Laboratory: Molecular Diagnostics 

Faculty/Authors
AIDA RICHARDSON, MD, PHD
SELVARAJ MUTHUSAMY, MD, PHD
DEEPIKA SIROHI, MD
DEPARTMENT OF PATHOLOGY
UNIVERSITY OF UTAH
Salt Lake City, Utah 
CMLE Credit: 2.0
Estimated Completion Time: 2 hour
Format: Online Educational Activity and Post Exam

Instructions

To claim CMLE credit for the exercise, do the following:

1. Review the Technical Considerations.
2. Click Go to Course to view an overview of the modules in this course.
3. Click Access to begin the course.
4. Review the Educational Activity.
5. Complete and submit the Post Exam.
6. Submit the course Evaluation to register your credit.

Faculty Disclosures​
The faculty have no relevant financial relationships with commercial interests to disclose.

Technical Considerations

Release Date: 05/27/2023
Review Date:
Expiration Date: 12/31/2025

• describe how mismatch repair (MMR) protein deficiency leads to microsatellite instability;

• discuss possible immunohistochemistry patterns seen in MMR deficiency, associated molecular results, and recommended follow-up testing;

• discuss pitfalls of MMR protein immunohistochemistry;

• explain the clinical significance of clonal loss of an MMR protein; and

• compare and contrast somatically acquired and germline MMR protein deficiency.