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LQCL2615 - CMLE - A Case of the Weakened Jka Allele
Course Description

LabQ 2026 Clinical Laboratory: Molecular Pathology 
 
Faculty/Authors

Katelin Ann Matthews, MLS (ASCP)
Rush University
Chicago, Illinois 

CMLE Credit: 2.0

Estimated Completion Time: 2 hour

Format: Online Educational Activity and Post Exam

Instructions

To claim CMLE credit for the exercise, do the following:

  1. Review the Technical Considerations.
  2. Click Go to Course to view an overview of the modules in this course.
  3. Click Access to begin the course.
  4. Review the Educational Activity.
  5. Complete and submit the Post Exam.
  6. Submit the course Evaluation to register your credit.

Faculty Disclosures​
The faculty have no relevant financial relationships with commercial interests to disclose.

Technical Considerations

Release Date: 3/31/2026 
Review Date:
Expiration Date: 12/31/2028  

Course Objectives
Following completion of this activity, you will be able to

  • summarize the genetic and molecular basis of the Kidd blood group system, including the role of the SLC14A1 gene; 

  • identify the molecular methods used to characterize a weakened Jka allele; 

  • recognize key genetic features of the JK*01 allele, including the 130G>A missense mutation and associated polymorphisms; and 

  • interpret molecular and serologic test results to differentiate between true Kidd-null phenotypes and weak antigen expression, including the implications of detecting variants such as the JK*01W.01. 

Summary
Availability:
On-Demand
Credit Offered:
2 CMLE Credits
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