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LQCL2617 - CMLE - Chronic Parvovirus B19 Infection Masking Potential Hyperhemolysis in an Adult Sickle Cell Patient: A Case Study of Transfusion-Related Anemia and Reaction Complications
Course Description

LabQ 2026 Clinical Laboratory: Transfusion Medicine 
 
Faculty/Authors

Jocelyn Rodrigue,
Medical Laboratory Scientist II, BB(ASCP)CM
University of Illinois Health
Chicago, Illinois 

CMLE Credit: 2.0

Estimated Completion Time: 2 hour

Format: Online Educational Activity and Post Exam

Instructions

To claim CMLE credit for the exercise, do the following:

  1. Review the Technical Considerations.
  2. Click Go to Course to view an overview of the modules in this course.
  3. Click Access to begin the course.
  4. Review the Educational Activity.
  5. Complete and submit the Post Exam.
  6. Submit the course Evaluation to register your credit.

Faculty Disclosures​
The faculty have no relevant financial relationships with commercial interests to disclose.

Technical Considerations

Release Date: 3/31/2026 
Review Date:
Expiration Date: 12/31/2028  

Course Objectives
Following completion of this activity, you will be able to

  • describe the pathophysiology of parvovirus B19 infection in sickle cell disease, including its role in erythroid aplasia and aplastic crisis; 

  • identify clinical and laboratory indicators that support or rule out hyperhemolysis syndrome in patients with sickle cell disease post-transfusion; 

  • interpret the significance of the direct antiglobulin test (DAT) and eluate results in investigating transfusion-related complications; and 

  • differentiate between febrile nonhemolytic transfusion reactions (FNHTR) and acute hemolytic transfusion reactions (AHTR) based on clinical signs and laboratory findings. 

Summary
Availability:
On-Demand
Credit Offered:
2 CMLE Credits
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