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LQHS2602 - CMLE - Unmasking Iron Overload: The Diagnostic Value of Special Stains in Liver Biopsy
Course Description

LabQ 2026 Histology 

Faculty/Authors

Amira S. Hamed, MD
Matt Andrew M. Paz, DO
Byoung Uk Park, MD 

Department of Laboratory Medicine and Pathology
University of Minnesota
Minneapolis, Minnesota 

CMLE Credit: 2.0

Estimated Completion Time: 2 hour
Format: Online Educational Activity and Post Exam

Instructions

To claim CMLE credit for the exercise, do the following:

  1. Review the Technical Considerations.
  2. Click Go to Course to view an overview of the modules in this course.
  3. Click Access to begin the course.
  4. Review the Educational Activity.
  5. Complete and submit the Post Exam.
  6. Submit the course Evaluation to register your credit.

Faculty Disclosures​
The faculty have no relevant financial relationships with commercial interests to disclose.

Technical Considerations

Release Date:  3/31/2026  
Review Date:
Expiration Date: 12/31/2028 

Course Objectives
Following completion of this activity, you will be able to:

  • describe the role of Perls iron stain in detecting and characterizing hepatic iron distribution; 

  • explain the diagnostic utility of periodic acid–Schiff with diastase (PAS-D) in evaluating α1-antitrypsin deficiency; 

  • outline the application of the trichrome stain in fibrosis staging; 

  • integrate special stain findings with clinical/laboratory data to resolve a diagnostic challenge; and 

  • recognize that, while H&E remains essential, special stains can provide critical details not otherwise discernible. 



Summary
Availability:
On-Demand
Credit Offered:
2 CMLE Credits
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