OasisLMS

Transplacental transfer of maternal T cells is a fairly common occurrence. In immunocompetent neonates, the endogenous T cells far outnumber the transplacentally-transferred maternal T cells, and this coupled with the 50% mismatch in the HLA allele makeup between the neonates and maternal cells allows for effective elimination of the maternal T cells. However, in neonates born with inborn errors of immunity that severely compromise endogenous T cell numerical and functional sufficiency, the transplacentally-transferred maternal T cells encounter an environment that permits successful engraftment. This can give rise to graft versus host disease (GVHD) mediated by the engrafted maternal T cells, and this requires prompt diagnosis and medical intervention.

Faculty/Authors

Khanolkar Aaruni

CME/CMLE Credit: 1.0
Estimated Completion Time: 1 hour
Format: Online Educational Activity

Accreditation Statement: The American Society for Clinical Pathology (ASCP) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME).

Credit Designation Statement: The American Society for Clinical Pathology (ASCP) designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions

To claim CME/CMLE credit for the exercise, do the following:

1. Review the Technical Considerations.
2. Review the Faculty Disclosures.
3. Click Go to Course to view an overview of the modules in this course.
4. Click Access to begin the course.
5. Submit the course Evaluation.
6. Enter the maximum number of credits offered and click Claim CME to register credit.

Technical Considerations

Release Date: 11/03/2025
Review Date:
Expiration Date: