LQCL2216 - CMLE - AN UNEXPECTED ANTIBODY-AN UNEXPECTED ANTIBODY

AN UNEXPECTED ANTIBODY

Pdf Summary

The document discusses a case study involving a 65-year-old man undergoing tumor removal, who was found to have an uncommon anti-N antibody despite no transfusion history. The laboratory performed various tests to identify and differentiate the antibody, ultimately determining it as an autoanti-‘Nf’ likely caused by smoking and reacting at the AHG phase, indicating clinical significance. The rarity of a true alloanti-N antibody is highlighted, with emphasis on ethnic backgrounds affecting antigen presence. Testing methods such as thermal amplitude studies, DTT treatment, and trypsin-treated cell tests are recommended to assess the clinical significance of the antibody. The document also provides background information on MNS antigens, emphasizing the protective effect of the ‘N’ antigen against immunization to the N antigen. It concludes with CMLE questions related to the content discussed, reinforcing key points covered in the document. The study underscores the importance of thorough investigation and testing in identifying and managing uncommon antibodies to ensure safe transfusions.

Keywords

tumor removal

anti-N antibody

autoanti-Nf

smoking

AHG phase

alloanti-N antibody

ethnic backgrounds

testing methods

MNS antigens

safe transfusions